Deciphering the molecular mechanism of axonal degeneration

We are studying the pathways promoting axon degeneration with the hopes of identifying new therapeutic targets for neuropathy and neurodegeneration. Using robotics and automated imaging systems, we have developed a high-throughput screening platform using primary sensory neuron cultures to find 1) small molecule inhibitors of axon degeneration, and 2) genes required for axon degeneration.

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