Daniel W. Summers, Ph.D., a postdoc in Dr. Jeff Milbrandt’s lab, recently had a paper published in PNAS. The paper, “Palmitoylation enables MAPK-dependent proteostasis of axon survival factors,” shows that intracellular location imparts sensitivity to distinct protein homeostasis networks, and inactivating multiple nodes in this protein homeostasis network confers maximal therapeutic potential in diseases of axon degeneration. Summers is first author on the paper and Dr. Jeff Milbrandt, James S. McDonnell Professor and Head of the Department of Genetics at Washington University School of Medicine in St. Louis, and Dr. Aaron DiAntonio, Professor of Developmental Biology at Washington University School of Medicine in St. Louis, are also authors on the paper.
Read the study abstract here.